Beilstein J. Org. Chem.2017,13, 1828–1849, doi:10.3762/bjoc.13.178
-sensitivity and corrosive nature of the sulfonylisocyanate reagent. In addition, these reagents are generally unavailable in comparison with sulfonamides, many of which are air-stable commercial chemicals [49].
In order to avoid using stoichiometric quantities of a base, a mechanochemical catalytic approach
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Graphical Abstract
Scheme 1:
a) Schematic representations of unsubstituted urea, thiourea and guanidine. b) Wöhler's synthesis o...